Inflammatory Bowel Diseases (IBD) develop due to chronic inflammation of GIT (the intestines more often). Crohn's disease and ulcerative colitis are the two major disorders included under IBD, Both the disorders are characterised by periods of exacerbations and remissions of varying severity The cause of IBD is still not clear, however, it is assumed to be the result of a genetic autoimmune state activated by an infection. The intestinal mucosa is made up of immune cells which on stimulation releases inflammatory mediators (e.g. histamine prostaglandins, leukotrienes, and cytokines). The function and neural activity of the secretory and smooth muscle cells in the GIT are influenced by inflammatory mediators Also an imbalance in fluid, electrolyte, and pH occurs. IBD may cause intense pain, weaken the patient, and may be fatal. Crohn's Disease A condition in which any part of the GIT (the proximal portion of colon more commonly and the terminal ileum less commonly) becomes in...
Comments
Post a Comment